Thimerosal-Containing Vaccines and Autistic Spectrum Disorder: A Critical Review of Published Original Data

@article{Parker2004ThimerosalContainingVA,
  title={Thimerosal-Containing Vaccines and Autistic Spectrum Disorder: A Critical Review of Published Original Data},
  author={Sarah K. Parker and B. Schwartz and J. Todd and L. Pickering},
  journal={Pediatrics},
  year={2004},
  volume={114},
  pages={793 - 804}
}
Objective. The issue of thimerosal-containing vaccines as a possible cause of autistic spectrum disorders (ASD) and neurodevelopmental disorders (NDDs) has been a controversial topic since 1999. Although most practitioners are familiar with the controversy, many are not familiar with the type or quality of evidence in published articles that have addressed this issue. To assess the quality of evidence assessing a potential association between thimerosal-containing vaccines and autism and… Expand
[Addressing the controversy regarding the association between thimerosal-containing vaccines and autism].
TLDR
The aim of this article is to review the literature for the main controversies about thimerosal in vaccines and its supposed association to autism, and concluded that the current available evidence do not support an association betweenThimerosal and childhood neurodevelopmental disorders, such as autism. Expand
Chelation Treatment for Autism Spectrum Disorders: A Systematic Review.
Abstract Chelation treatment is used to eliminate specific metals from the body, such as mercury. It has been hypothesized that mercury poisoning may be a factor in autism and data suggest thatExpand
Mercury in vaccines: A review
Introduction: Mercury in the form of thiomersal has been used as a preservative in vaccines since 1930s. The association of autism and other neurological deficits following mercury exposure throughExpand
Thiomersal-containing vaccines - a review of the current state of knowledge.
TLDR
There are no contraindications to the use of vaccines with thiomersal in infants, children and non-pregnant women, and the risk of serious complications associated with the development of diseases in unvaccinated individuals far outweighs the potential risk of adverse consequences associated with immunization with thuomersal. Expand
Autistic spectrum disorder: No causal relationship with vaccines.
TLDR
The present article reviews recent controversies surrounding immunizations and ASD, and concludes that there are no data to support any association between immunization and ASD. Expand
Nutritional and environmental approaches to preventing and treating autism and attention deficit hyperactivity disorder (ADHD): a review.
TLDR
Larger studies are needed to determine optimum multifactorial treatment plans involving nutrition, environmental control,medication, and behavioral/education/speech/physical therapies. Expand
Immunizations and Autism: A Review of the Literature
  • A. Doja, W. Roberts
  • Medicine
  • Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
  • 2006
TLDR
A literature review found very few studies supporting this theory, with the overwhelming majority showing no causal association between the Measles-Mumps-Rubella vaccine and autism. Expand
Pharmacotherapy and Bumetanide in Autism Treatment
TLDR
The pharmacological treatment approaches of autism, the targeted new treatment mechanisms, the association between intracellular chloride concentration with autism are mentioned respectively, and bumetanide, one of the most studied chemicals in the past decade, is reviewed. Expand
Increasing exposure to antibody-stimulating proteins and polysaccharides in vaccines is not associated with risk of autism.
TLDR
Increasing exposure to antibody-stimulating proteins and polysaccharides in vaccines during the first 2 years of life was not related to the risk of developing an ASD in MCO members. Expand
Thimerosal disappears but autism remains.
TLDR
In 2004, the Institute of Medicine Immunization Safety Review Committee reviewed all evidence available from epidemio-logic, biological, molecular, and animal model studies and concluded that the evidence favored the rejection of both hypotheses with respect to the risk of autism. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 73 REFERENCES
Thimerosal-Containing Vaccines and Autistic Spectrum Disorder: A Critical Review of Published Original Data
TLDR
Evidence does not support a change in the standard of practice with regard to administration of thimerosal-containing vaccines in areas of the world where they are used, and the pharmacokinetics of ethylmercury make such an association less likely. Expand
Association between thimerosal-containing vaccine and autism.
TLDR
The results do not support a causal relationship between childhood vaccination with thimerosal-containing vaccines and development of autistic-spectrum disorders. Expand
Autism and thimerosal-containing vaccines: lack of consistent evidence for an association.
TLDR
The body of existing data, including the ecologic data presented herein, is not consistent with the hypothesis that increased exposure to Thimerosal-containing vaccines is responsible for the apparent increase in the rates of autism in young children being observed worldwide. Expand
Neurodevelopmental Disorders after Thimerosal-Containing Vaccines: A Brief Communication
TLDR
An association between neurodevelopmental disorders and thimerosal-containing DTaP vaccines was found, but additional studies should be conducted to confirm and extend this study. Expand
Thimerosal Exposure in Infants and Developmental Disorders: A Retrospective Cohort Study in the United Kingdom Does Not Support a Causal Association
TLDR
With the possible exception of tics, there was no evidence that thimerosal exposure via DTP/DT vaccines causes neurodevelopmental disorders. Expand
An assessment of the impact of thimerosal on childhood neurodevelopmental disorders
TLDR
The evidence presented here shows that the occurrence of neurodevelopmental disorders following thimerosal-containing childhood vaccines does not appear to be coincidental. Expand
Thimerosal and the occurrence of autism: negative ecological evidence from Danish population-based data.
TLDR
The ecological data do not support a correlation between thimerosal-containing vaccines and the incidence of autism. Expand
The role of mercury in the pathogenesis of autism
TLDR
Confirmation of thimerosal as an environmental agent in autism pathogenesis has important societal and patient implications. Expand
Thimerosal Exposure in Infants and Developmental Disorders: A Prospective Cohort Study in the United Kingdom Does Not Support a Causal Association
TLDR
A large United Kingdom population–based cohort study on childhood health and development could find no convincing evidence that early exposure to thimerosal had any deleterious effect on neurologic or psychological outcome. Expand
A comparative evaluation of the effects of MMR immunization and mercury doses from thimerosal-containing childhood vaccines on the population prevalence of autism.
  • D. Geier, M. Geier
  • Medicine
  • Medical science monitor : international medical journal of experimental and clinical research
  • 2004
TLDR
There was a close correlation between mercury doses from thimerosal--containing childhood vaccines and the prevalence of autism from the late 1980s through the mid-1990s and additional research be undertaken to produce a MMR vaccine with an improved safety profile. Expand
...
1
2
3
4
5
...