Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.

@article{Scott2008ThienopyridoneDA,
  title={Thienopyridone drugs are selective activators of AMP-activated protein kinase beta1-containing complexes.},
  author={John W Scott and Bryce J. W. van Denderen and Sebastian Beck Jorgensen and Jane E. Honeyman and Gregory R Steinberg and Jonathan S. Oakhill and Tristan J. Iseli and Ann Zhufang Koay and Paul R. Gooley and David Stapleton and Bruce E. Kemp},
  journal={Chemistry & biology},
  year={2008},
  volume={15 11},
  pages={1220-30}
}
The AMP-activated protein kinase (AMPK) is an alphabetagamma heterotrimer that plays a pivotal role in regulating cellular and whole-body metabolism. Activation of AMPK reverses many of the metabolic defects associated with obesity and type 2 diabetes, and therefore AMPK is considered a promising target for drugs to treat these diseases. Recently, the thienopyridone A769662 has been reported to directly activate AMPK by an unexpected mechanism. Here we show that A769662 activates AMPK by a… CONTINUE READING

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Tumor necrosis factor a-induced skeletal muscle insulin resistance involves suppression of AMP-kinase signaling

  • G. R. Steinberg, B. J. Michell, +7 authors D Carling
  • Cell Metab
  • 2006
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