Thienopyridines in cardiovascular disease: focus on clopidogrel resistance.

  title={Thienopyridines in cardiovascular disease: focus on clopidogrel resistance.},
  author={Jolanta Maria Siller-Matula and Karsten Schroer and Johann Wojta and Kurt Huber},
  journal={Thrombosis and haemostasis},
  volume={97 3},
Platelets play an important role in atherothrombotic disease, as well as in the pathogenesis of atherosclerosis and in complications. Antiplatelet therapy with clopidogrel represents at present an important treatment of coronary artery disease (CAD), especially in and after acute coronary syndromes (ACS), and after coronary interventions when stents are used. Clopidogrel is a potent and specific inhibitor of platelet ADP receptor (P2Y(12) receptor) with high antithrombotic activity. Emerging… CONTINUE READING


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