Thick-filament-linked calcium regulation in vertebrate striated muscle

@article{Lehman1978ThickfilamentlinkedCR,
  title={Thick-filament-linked calcium regulation in vertebrate striated muscle},
  author={William Lehman},
  journal={Nature},
  year={1978},
  volume={274},
  pages={80-81}
}
CALCIUM is the trigger initiating muscular contraction, and relaxation occurs on its removal. As contraction is caused by the cyclic attachment and detachment of myosin-crossbridges of the thick filament with actin of the thin filament, calcium, in principle, could modify muscular activity by affecting regulatory systems on either the thick or the thin filaments. It is generally accepted that a thin-filament-linked Ca2+-regulatory system, involving troponin and tropomyosin, is responsible, at… CONTINUE READING
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