Thiazolodiazepines: New Ultra-short Acting Hypnotics


The synthesis and hypnotic evaluation of a new generation of thiazolo[3,2-a][1,3]diazepine analogs are described. Those compounds exhibit potent in vivo activities as ultra-short acting hypnotics. Background of the Invention Surgical procedures require the administration of several intravenous drugs to ensure hypnosis, analgesia, relaxation and control of visceral reflex responses. The use of intravenous drugs adds flexibility and permits the administration of lower doses of inhalational anesthetic agents. Intravenous anesthetic, appropriate to the requirements of surgery, becomes available with the introduction of thiopental, an ultrashort -acting barbiturate. General anesthesia most often is initiated by an injection

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@inproceedings{ElSubbagh2007ThiazolodiazepinesNU, title={Thiazolodiazepines: New Ultra-short Acting Hypnotics}, author={Hussein Ibrahim El-Subbagh}, year={2007} }