Thiazolo[4,5-d]pyrimidine thiones and -ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists.

@article{Beck1999Thiazolo45dpyrimidineTA,
  title={Thiazolo[4,5-d]pyrimidine thiones and -ones as corticotropin-releasing hormone (CRH-R1) receptor antagonists.},
  author={James P. Beck and Michael A. Curry and R J Chorvat and Lawrence W. Fitzgerald and Paul J. Gilligan and Robert C. Zaczek and George L Trainor},
  journal={Bioorganic & medicinal chemistry letters},
  year={1999},
  volume={9 8},
  pages={1185-8}
}
A series of thiazolo[4,5-d]pyrimidine thiones and -ones was prepared and discovered to have good binding affinity to the CRH-R1 receptor, thus showing promise as a new class of potential anxiolytics and/or antidepressants.