Thiazolidinediones provide better renoprotection than insulin in an obese, hypertensive type II diabetic rat model.

@article{Ohtomo2007ThiazolidinedionesPB,
  title={Thiazolidinediones provide better renoprotection than insulin in an obese, hypertensive type II diabetic rat model.},
  author={Shuichi Ohtomo and Yuko Izuhara and Shunya Takizawa and Norio Yamada and Takatoshi Kakuta and Charles van Ypersele de Strihou and Toshio Miyata},
  journal={Kidney international},
  year={2007},
  volume={72 12},
  pages={
          1512-9
        }
}
Hyperinsulinemia has been implicated in the development of diabetic nephropathy. In the present study we compared the renoprotective effects of the thiazolidinedione, pioglitazone (PGZ), to that of insulin in a hypertensive, obese, type II diabetic rat model. PGZ aggravated obesity and gave less glycemic control than insulin. However, renoprotection was markedly better with PZG compared to insulin as shown by lower proteinuria, improved renal function, and less histological evidence of diabetic… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 27 CITATIONS