Thiazolidinediones inhibit the progression of established hypertension in the Dahl salt-sensitive rat.

@article{Bolten2007ThiazolidinedionesIT,
  title={Thiazolidinediones inhibit the progression of established hypertension in the Dahl salt-sensitive rat.},
  author={Charles W. Bolten and Maria A. Payne and William G. McDonald and Patrick M. Blanner and Robert C Chott and Sarbani Laskar Ghosh and Graciela B. Arhancet and Nicholas R. Staten and Eric Arthur Gulve and Patrick M Sullivan and Alexander E. Hromockyj and Jerry Raymond Colca},
  journal={Diabetes & vascular disease research},
  year={2007},
  volume={4 2},
  pages={117-23}
}
We evaluated the effects of two thiazolidinediones (TZDs), the potent PPARgamma agonist rosiglitazone currently being used to treat diabetes, and a structurally similar experimental compound that is a poor PPARgamma agonist, in a non-diabetic, established hypertension model with continuous measurement of blood pressure by telemetry. Hypertension was induced in male Dahl salt-sensitive rats by a three-week pre-treatment with 4% salt before initiation of treatment. Fasting blood samples were… CONTINUE READING

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