Thiazolidinediones inhibit osteoclast-like cell formation and bone resorption in vitro.

@article{Okazaki1999ThiazolidinedionesIO,
  title={Thiazolidinediones inhibit osteoclast-like cell formation and bone resorption in vitro.},
  author={Ryo Okazaki and Masaaki Toriumi and Seiji Fukumoto and Masaaki Miyamoto and Toshiro Fujita and Koshi Tanaka and Yasuhiro Takeuchi},
  journal={Endocrinology},
  year={1999},
  volume={140 11},
  pages={5060-5}
}
Osteoblasts and adipocytes are derived from common bone marrow stromal cells that play crucial roles in the generation of osteoclasts. Activation of peroxisome proliferator-activated receptor-gamma (PPARgamma) induces adipogenic differentiation of stromal cells; however, whether this would affect osteoblast/osteoclast differentiation is unknown. Thus, we examined the effects of the thiazolidinedione (TZD) class of antidiabetic agents that activate PPARgamma on osteoblast/osteoclast… CONTINUE READING

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