Thiazolidinediones inhibit REG Ialpha gene transcription in gastrointestinal cancer cells.

@article{Yamauchi2009ThiazolidinedionesIR,
  title={Thiazolidinediones inhibit REG Ialpha gene transcription in gastrointestinal cancer cells.},
  author={Akiyo Yamauchi and Iwao Takahashi and Shin Takasawa and K Gopi Nata and Naoya Noguchi and Takayuki Ikeda and Takeo Yoshikawa and Nausheen Jamal Shervani and Iwao Suzuki and Akira Uruno and Michiaki Unno and Hiroshi Okamoto and Akira Sugawara},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={379 3},
  pages={
          743-8
        }
}
REG (Regenerating gene) Ialpha protein functions as a growth factor for gastrointestinal cancer cells, and its mRNA expression is strongly associated with a poor prognosis in gastrointestinal cancer patients. We here demonstrated that PPARgamma-agonist thiazolidinediones (TZDs) inhibited cell proliferation and REG Ialpha protein/mRNA expression in gastrointestinal cancer cells. TZDs inhibited the REG Ialpha gene promoter activity, via its cis-acting element which lacked PPAR response element… CONTINUE READING
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