Thiazolidinediones improve hepatic fibrosis in rats with non-alcoholic steatohepatitis by activating the adenosine monophosphate-activated protein kinase signalling pathway.

@article{Zhang2012ThiazolidinedionesIH,
  title={Thiazolidinediones improve hepatic fibrosis in rats with non-alcoholic steatohepatitis by activating the adenosine monophosphate-activated protein kinase signalling pathway.},
  author={Wei Zhang and Rong Y Wu and Feng Zhang and Yizhi Xu and Bo Yang Victor Liu and Yingying Yang and Huamei Zhou and Lulu Wang and Keqiang Wan and Xiaoqiu Xiao and Xia Zhang},
  journal={Clinical and experimental pharmacology & physiology},
  year={2012},
  volume={39 12},
  pages={1026-33}
}
Thiazolidinediones (TZDs) markedly reduce hepatic steatosis in both rodents and humans. However, the effects and mechanisms of action of TZDs on hepatic fibrosis remain unclear. The aim of the present study was to determine the effects of TZDs on histological changes in the liver and on the modulation by adiponectin via the AMP-activated protein kinase (AMPK) signalling pathway in rats with non-alcoholic steatohepatitis (NASH). Forty rats were divided into normal control, high-fat diet (HFD… CONTINUE READING
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