Thiazolidinediones improve beta-cell function in type 2 diabetic patients.

@article{Gastaldelli2007ThiazolidinedionesIB,
  title={Thiazolidinediones improve beta-cell function in type 2 diabetic patients.},
  author={Amalia Gastaldelli and Ele Ferrannini and Yoshinori Miyazaki and Masafumi Matsuda and Andrea Mari and Ralph A DeFronzo},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2007},
  volume={292 3},
  pages={
          E871-83
        }
}
Thiazolidinediones (TZDs) improve glycemic control and insulin sensitivity in patients with type 2 diabetes mellitus (T2DM). There is growing evidence from in vivo and in vitro studies that TZDs improve pancreatic beta-cell function. The aim of this study was to determine whether TZD-induced improvement in glycemic control is associated with improved beta-cell function. We studied 11 normal glucose-tolerant and 53 T2DM subjects [age 53+/-2 yr; BMI 29.4+/-0.8 kg/m2; fasting plasma glucose (FPG… CONTINUE READING

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