Thiazolidinediones exert different effects on insulin resistance between dexamethasone-treated rats and wistar fatty rats.

@article{Kimura2000ThiazolidinedionesED,
  title={Thiazolidinediones exert different effects on insulin resistance between dexamethasone-treated rats and wistar fatty rats.},
  author={Michio Kimura and Makoto Daimon and Michiaki Tominaga and Hideo Manaka and Hajime Sasaki and Takeo Kato},
  journal={Endocrine journal},
  year={2000},
  volume={47 1},
  pages={21-8}
}
We determined the in vivo effects of thiazolidinediones on insulin resistance induced by dexamethasone (Dx), as well as that observed in Wistar fatty (WF) rats, using glucose clamp technique to measure glucose uptake (Gu) and percent suppression of hepatic glucose output (HGOsup) to evaluate insulin resistance. Male Wistar rats were treated with Dx (0.5 mg/kg/day) for 7 days. Pioglitazone (P) or troglitazone (T) was coadministered orally for the same period at 10 and 200 mg/kg/day, respectively… CONTINUE READING