Thiazolidinediones and the renal and hormonal response to water immersion-induced volume expansion in type 2 diabetes mellitus.

@article{Goenka2008ThiazolidinedionesAT,
  title={Thiazolidinediones and the renal and hormonal response to water immersion-induced volume expansion in type 2 diabetes mellitus.},
  author={Niru Goenka and Christina Kotonya and Michael D H Penney and Harpal Randeva and Joseph Paul O'Hare},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2008},
  volume={294 4},
  pages={E733-9}
}
Thiazolidinediones cause sodium retention and edema by a direct effect on the kidneys. The aim of this study was to use the technique of head-out water immersion to investigate the effects of rosiglitazone on sodium and volume homeostasis in subjects with type 2 diabetes mellitus. The volume expansion response to water immersion was compared with the response on a non-immersion control day in 12 nondiabetic male subjects and 8 diet-controlled male type 2 diabetic subjects with hourly blood and… CONTINUE READING

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TZDS AND VOLUME EXPANSION IN TYPE 2 DIABETES AJP-Endocrinol Metab

  • RW Nesto, D Bell, +9 authors R. Kahn
  • APRIL
  • 2008
2 Excerpts

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