Thiazolidinediones: Pleiotropic drugs with potent anti-inflammatory properties for tissue protection.

@article{Buckingham2005ThiazolidinedionesPD,
  title={Thiazolidinediones: Pleiotropic drugs with potent anti-inflammatory properties for tissue protection.},
  author={Robin E Buckingham},
  journal={Hepatology research : the official journal of the Japan Society of Hepatology},
  year={2005},
  volume={33 2},
  pages={167-70}
}
Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a nuclear transcription factor that comprises the primary molecular target for thiazolidinedione (TZD) insulin-sensitizing drugs. Whilst expressed in many tissues in humans, its abundant expression in adipose tissue is believed to be the focal point through which TZDs regulate genes involved in glucose and lipid metabolism and via which these agents ultimately improve the hyperglycemia of type 2 diabetes. However, TZDs exhibit many… CONTINUE READING

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