Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes.

@article{Digby1998ThiazolidinedioneEI,
  title={Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes.},
  author={Janet E. Digby and Carl T. Montague and Ciaran P. Sewter and Linda Sanders and William O. Wilkison and Stephen O'Rahilly and Johannes B. Prins},
  journal={Diabetes},
  year={1998},
  volume={47 1},
  pages={138-41}
}
Thiazolidinediones (TZDs) are a novel class of insulin-sensitizing agents used in the treatment of NIDDM and are potent agonists for the nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARgamma). The thiazolidinedione BRL 49653 has been shown to promote the differentiation of the HIB-1B brown preadipocyte cell line and to increase rat interscapular brown adipose tissue (BAT) mass. Given the importance of brown fat in the control of energy metabolism in rodents, this… CONTINUE READING