Thiazole fused thiosemicarbazones: Microwave-assisted synthesis, biological evaluation and molecular docking study

@article{Prajapati2019ThiazoleFT,
  title={Thiazole fused thiosemicarbazones: Microwave-assisted synthesis, biological evaluation and molecular docking study},
  author={Neelam P. Prajapati and Kinjal D. Patel and Rajesh H. Vekariya and Hitesh D. Patel and Dhanaji P. Rajani},
  journal={Journal of Molecular Structure},
  year={2019}
}
View via Publisher
15 Citations
Background Citations
2

15 Citations

Design, synthesis, molecular docking and biological screening of N-ethyl-N-methylbenzenesulfonamide derivatives as effective antimicrobial and antiproliferative agents
Synthesis of thiazolylidenethiazoloquinazolinone hybrids from monocarbonyl curcumin analogues. Characterization, bio-evaluation and DFT study
Given the diverse pharmacological attributes possessed by the curcumin and its analogs, quinazolinethione 3, thiazoloquinazolinone 4, and thiazolylidene thiazoloquinazolinone hybrids D1-D12 were…
Synthesis and Identification of some new Derivatives Oxazole, Thiazole and Imidazol from Acetyl Cysteine
Some fused heterocyclic oxazoles and imidazols rings were synthesized from reaction of N- acetyl cysteine with different treatment. After thiol group protection, N-acetyl-S-ethyl cysteine (2) had…
An Overview of the Synthesis and Antimicrobial, Antiprotozoal, and Antitumor Activity of Thiazole and Bisthiazole Derivatives
TLDR
The current review provides an overview of different methods for the synthesis of thiazole and bisthiazole derivatives and describes various compounds bearing a thiazolic moiety possessing antibacterial, antifungal, antiprotozoal, and antitumor activity, encouraging further research on the discovery ofThiazole-containing drugs.
Synthesis of novel scaffolds based on thiazole or triazolothiadiazine linked to benzofuran or benzo[d]thiazole moieties as new hybrid molecules
Abstract A synthesis of novel hybrid molecules containing thiazole or bis(thiazoles) each bearing benzofuran and/or benzo[d]thiazole moieties by the reaction of the appropriate thioamide derivatives…
Computational approximations of molecularly imprinted polymers with sulphur based monomers for biological purposes
“Room temperature Imidazolium linked Chalcone based Ionic LCs: Role of Terminal position on Mesomorphism”
Design and synthesis of novel benzimidazole linked thiazole derivatives as promising inhibitors of drug-resistant tuberculosis
Thiazole derivatives in medicinal chemistry: Recent advancements in synthetic strategies, structure activity relationship and pharmacological outcomes
Design, synthesis, docking study, and anticancer evaluation of novel bis-thiazole derivatives linked to benzofuran or benzothiazole moieties as PI3k inhibitors and apoptosis inducers
...
...

References

SHOWING 1-10 OF 29 REFERENCES
Synthesis and biological evaluation of some novel thiazole compounds as potential anti-inflammatory agents.
Synthesis of some new 2,4-disubstituted thiazoles as possible antibacterial and anti-inflammatory agents.
Structure-activity relationship (SAR) study and design strategies of nitrogen-containing heterocyclic moieties for their anticancer activities.
Microwave and ultrasound-assisted synthesis of thiosemicarbazones and their corresponding (4,5-substituted-thiazol-2-yl)hydrazines
Hantzsch cyclization of thiosemicarbazone intermediates is a very popular approach to the synthesis of substituted thiazoles. We developed a convenient microwave and ultrasound-assisted method both…
Novel 1-indanone Thiosemicarbazone Antiviral Candidates: Aqueous Solubilization and Physical Stabilization by Means of Cyclodextrins
TLDR
1-indanone TSC/CD inclusion complexes improved aqueous solubility and physical stability of these new drug candidates and constitute a promising technological approach towards evaluation of their activity against the viruses hepatitis B and C.
Synthesis and anticancer activity of thiosemicarbazones.
Syntheses and biological activities of bis(3-indolyl)thiazoles, analogues of marine bis(indole)alkaloid nortopsentins.
A Review on Biological Activity of Imidazole and Thiazole Moieties and their Derivatives
TLDR
This articles aims to review the work reported, their chemistry and biological activities of imidazole and thiazole during past years and to synthesize a large number of novel chemotherapeutic agents.
Heterocyclic Anticancer Compounds: Recent Advances and the Paradigm Shift towards the Use of Nanomedicine’s Tool Box
TLDR
This review provides for a concise overview of heterocyclic active compounds and families and their main applications in medicine, focusing on those suitable for cancer therapy while simultaneously addressing main biochemical modes of action, biological targets, structure-activity relationships as well as intrinsic limitation issues in the use of these compounds.
Biological Potential of Thiazole Derivatives of Synthetic Origin
TLDR
A broad view on biological activities of compounds having thiazole nucleus is highlighted and similar compounds synthesized through different routes bear variable magnitudes of biological activities.
...
...