Thiazide treatment of rats provokes apoptosis in distal tubule cells.

  title={Thiazide treatment of rats provokes apoptosis in distal tubule cells.},
  author={Johannes Loffing and Dominique Loffing-Cueni and Ivan Hegyi and Miriam R. Kaplan and Steven C. Hebert and Michel Le Hir and Brigitte Kaissling},
  journal={Kidney international},
  volume={50 4},
We studied the effects of inhibition of apical NaCl entry on the structural correlates for electrolyte transport in the distal convoluted tubule (DCT) of rats. Thiazide diuretics were used to block NaCl entry specifically in the DCT. Metolazone or hydrochlorothiazide (HCTZ) were applied for three days subcutaneously via osmotic minipumps. The renal epithelial structure of control and treated rats was studied by light and electron microscopy. Distribution of the thiazide-sensitive NaCl… CONTINUE READING


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