Thiazide effects and adverse effects: insights from molecular genetics.

@article{Ellison2009ThiazideEA,
  title={Thiazide effects and adverse effects: insights from molecular genetics.},
  author={David H Ellison and Johannes Loffing},
  journal={Hypertension},
  year={2009},
  volume={54 2},
  pages={196-202}
}
One of the longest-running debates in clinical medicine shows no sign of disappearing; just when it seems that thiazides have reassumed their role as front-line drugs to treat hypertension,1 new concerns emerge,2–4 leading some to question their role once again.5 Thiazides are effective antihypertensives with long track records and low cost. The major concerns about their use arise from their tendency to cause hypokalemia, impair glucose tolerance, increase serum cholesterol, and increase serum… CONTINUE READING
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