Thiazide diuretics directly induce osteoblast differentiation and mineralized nodule formation by interacting with a sodium chloride co-transporter in bone.

@article{Dvorak2007ThiazideDD,
  title={Thiazide diuretics directly induce osteoblast differentiation and mineralized nodule formation by interacting with a sodium chloride co-transporter in bone.},
  author={Melita M Dvorak and Cyrille de Joussineau and Duncan Howard Carter and Trairak Pisitkun and Mark A. Knepper and Gerardo Gamba and Paul J Kemp and Daniela Riccardi},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2007},
  volume={18 9},
  pages={2509-16}
}
Thiazide diuretics are used worldwide as a first-choice drug for patients with uncomplicated hypertension. In addition to their antihypertensive effect, thiazides increase bone mineral density and reduce the prevalence of fractures. Traditionally, these effects have been attributed to increased renal calcium reabsorption that occurs secondary to the inhibition of the thiazide-sensitive sodium chloride cotransporter (NCC) in the distal tubule. The aim of the current study was to determine… CONTINUE READING
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