Thiaminylated adenine nucleotides. Chemical synthesis, structural characterization and natural occurrence

@article{Frdrich2009ThiaminylatedAN,
  title={Thiaminylated adenine nucleotides. Chemical synthesis, structural characterization and natural occurrence},
  author={Michel Fr{\'e}d{\'e}rich and David Delvaux and Tiziana Gigliobianco and Marjorie Gangolf and Georges Dive and Gabriel Mazzucchelli and Benjamin Elias and Edwin De Pauw and Luc Angenot and Pierre Wins and Lucien Bettendorff},
  journal={The FEBS Journal},
  year={2009},
  volume={276}
}
Thiamine and its three phosphorylated derivatives (mono‐, di‐ and triphosphate) occur naturally in most cells. Recently, we reported the presence of a fourth thiamine derivative, adenosine thiamine triphosphate, produced in Escherichia coli in response to carbon starvation. Here, we show that the chemical synthesis of adenosine thiamine triphosphate leads to another new compound, adenosine thiamine diphosphate, as a side product. The structure of both compounds was confirmed by MS analysis and… Expand
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