Thiamine triphosphate and thiamine triphosphatase activities: from bacteria to mammals

  title={Thiamine triphosphate and thiamine triphosphatase activities: from bacteria to mammals},
  author={Alexander F Makarchikov and Bernard Lakaye and I. E. Gulyai and Jan Czerniecki and Bernard Coumans and Pierre Wins and Thierry Grisar and Lucien Bettendorff},
  journal={Cellular and Molecular Life Sciences CMLS},
In most organisms, the main form of thiamine is the coenzyme thiamine diphosphate. Thiamine triphosphate (ThTP) is also found in low amounts in most vertebrate tissues and can phosphorylate certain proteins. Here we show that ThTP exists not only in vertebrates but is present in bacteria, fungi, plants and invertebrates. Unexpectedly, we found that in Escherichia coli as well as in Arabidopsis thaliana, ThTP was synthesized only under particular circumstances such as hypoxia (E. coli) or… CONTINUE READING
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Molecular characterization of a specific thiamine triphosphatase widely expressed in mammalian tissues

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