Thiamine mimetics sulbutiamine and benfotiamine as a nutraceutical approach to anticancer therapy.

  title={Thiamine mimetics sulbutiamine and benfotiamine as a nutraceutical approach to anticancer therapy.},
  author={Hunter C. Jonus and Charnel C Byrnes and Jaeah Kim and M. La Valle and Michael G. Bartlett and Hamid M Said and Jason Zastre},
  journal={Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
Malignant cells frequently demonstrate an oncogenic-driven reliance on glycolytic metabolism to support their highly proliferative nature. Overexpression of pyruvate dehydrogenase kinase (PDK) may promote this unique metabolic signature of tumor cells by inhibiting mitochondrial function. PDKs function to phosphorylate and inhibit pyruvate dehydrogenase (PDH) activity. Silencing of PDK expression has previously been shown to restore mitochondrial function and reduce tumor cell proliferation… Expand
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