Thiamine-dependent enzyme changes in the brains of alcoholics: relationship to the Wernicke-Korsakoff syndrome.

@article{Butterworth1993ThiaminedependentEC,
  title={Thiamine-dependent enzyme changes in the brains of alcoholics: relationship to the Wernicke-Korsakoff syndrome.},
  author={Roger F. Butterworth and Jillian J. Kril and Clive G. Harper},
  journal={Alcoholism, clinical and experimental research},
  year={1993},
  volume={17 5},
  pages={1084-8}
}
Chronic alcoholism results in thiamine deficiency as a consequence of poor nutrition, impaired absorption, and decreased phosphorylation to the enzyme cofactor form of the vitamin, thiamine pyrophosphate (TPP). Results of this study demonstrate significant reductions of TPP-dependent enzymes [pyruvate dehydrogenase complex, alpha-ketoglutarate dehydrogenase… CONTINUE READING