Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease

@article{Butterworth1990ThiaminedependentEC,
  title={Thiamine-dependent enzyme changes in temporal cortex of patients with Alzheimer's disease},
  author={Roger F. Butterworth and Anne -Marie Besnard},
  journal={Metabolic Brain Disease},
  year={1990},
  volume={5},
  pages={179-184}
}
Activites of thiamine-dependent enzymes [pyruvate dehydrogenase (PDHC), α-ketoglutarate dehydrogenase (αKGDH), and transketolase (TK)] were measured in autopsied samples of temporal cortex from six patients with Alzheimer's disease and from eight age-matched control subjects who were free from neurological or psychiatric diseases. Times from death to freezing of dissected material at −70°C were matched. Significant decreases in PDHC (decreased by 70%;P<0.01), αKGDH (decreased by 70%; p<0.01… CONTINUE READING
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