Thiamine attenuates hypoxia-induced cell death in cultured neonatal rat cardiomyocytes.

@article{Shin2004ThiamineAH,
  title={Thiamine attenuates hypoxia-induced cell death in cultured neonatal rat cardiomyocytes.},
  author={Bo Hee Shin and Seung Hyuk Choi and Eun Young Cho and Min-Jeong Shin and K. T. Hwang and Hong K. Cho and Ji Hyung Chung and Yangsoo Jang},
  journal={Molecules and cells},
  year={2004},
  volume={18 2},
  pages={133-40}
}
Previous studies have demonstrated that thiamine (vitamin B1) has a cytoprotective effect against ischemic damage to the heart, and that heat shock protein 70 (Hsp70) is capable of protecting cardiac cells from lethal ischemia/hypoxia. We show here that thiamine has a cytoprotective effect on cultured neonatal rat cardiomyocytes under hypoxic insult, and also protects the cardiomyocytes against hypoxia-induced apoptosis; caspase-3 activation, PARP cleavage and DNA fragmentation are all… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Similar Papers

Loading similar papers…