Thiamine and magnesium deficiencies: keys to disease.

@article{Lonsdale2015ThiamineAM,
  title={Thiamine and magnesium deficiencies: keys to disease.},
  author={D. Lonsdale},
  journal={Medical hypotheses},
  year={2015},
  volume={84 2},
  pages={
          129-34
        }
}
  • D. Lonsdale
  • Published 2015
  • Biology, Medicine
  • Medical hypotheses
Thiamine deficiency (TD) is accepted as the cause of beriberi because of its action in the metabolism of simple carbohydrates, mainly as the rate limiting cofactor for the dehydrogenases of pyruvate and alpha-ketoglutarate, both being critical to the action of the citric acid cycle. Transketolase, dependent on thiamine and magnesium, occurs twice in the oxidative pentose pathway, important in production of reducing equivalents. Thiamine is also a cofactor in the dehydrogenase complex in the… Expand
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TLDR
In the later study vitamins of the B complex, other than thiamine, were provided by administration of 20 Gm. Expand
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  • Medicine
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TLDR
Dysautonomic symptoms observed are compared with those seen in classical beriberi, the nutritional prototype for dysautonomia, and changes in blood pressure are described which support that the biochemical lesion might be due to malabsorption of thiamin or its inadequate phosphorylation. Expand
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TLDR
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TLDR
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  • Biology, Medicine
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TLDR
Results indicate thiamine deficiency induces HIF-1α-mediated gene expression similar to that observed in hypoxic stress, and may provide evidence for a central transcriptional response associated with the clinical manifestations of thiamines deficiency. Expand
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TLDR
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TLDR
The symptoms in all 20 patients could be correlated with those well documented in early beriberi and all were clinically improved by the administration of thiamin and in 10 patients improved transketolase activity was correlated with clinical well-being. Expand
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TLDR
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