Thiamine and cyanocobalamin relieve neuropathic pain in rats: synergy with dexamethasone.

@article{CaramSalas2006ThiamineAC,
  title={Thiamine and cyanocobalamin relieve neuropathic pain in rats: synergy with dexamethasone.},
  author={Nadia L Caram-Salas and Gerardo Reyes-Garc{\'i}a and Roberto Medina-Santill{\'a}n and Vinicio Granados-Soto},
  journal={Pharmacology},
  year={2006},
  volume={77 2},
  pages={53-62}
}
Treatment of neuropathic pain is an area of largely unmet medical need. Therefore, this pain may require the development of novel drug entities. In the search for alternatives, B vitamins have been found to be a clinically useful pharmacological tool for patients with neuropathic pain. However, preclinical studies supporting this use are lacking. In this study, we assessed the possible antiallodynic effects of thiamine, pyridoxine, and cyanocobalamin as well as dexamethasone and their… CONTINUE READING

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