Thiamine and benfotiamine improve cognition and ameliorate GSK-3β-associated stress-induced behaviours in mice

@article{Markova2017ThiamineAB,
  title={Thiamine and benfotiamine improve cognition and ameliorate GSK-3$\beta$-associated stress-induced behaviours in mice},
  author={Nataliia Markova and N P Bazhenova and Daniel C. Anthony and Julie Vignisse and Andrey A. Svistunov and Klaus-Peter Lesch and Lucien Bettendorff and Tatyana Strekalova},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2017},
  volume={75},
  pages={148-156}
}
ABSTRACT Thiamine (vitamin B1) deficiency in the brain has been implicated in the development of dementia and symptoms of depression. Indirect evidence suggests that thiamine may contribute to these pathologies by controlling the activities of glycogen synthase kinase (GSK)‐3&bgr;. While decreased GSK‐3&bgr; activity appears to impair memory, increased GSK‐3&bgr; activity is associated with the distressed/depressed state. However, hitherto direct evidence for the effects of thiamine on GSK‐3… Expand
Oral benfotiamine reverts cognitive deficit and increase thiamine diphosphate levels in the brain of a rat model of neurodegeneration
TLDR
Results suggest that benfotiamine could be a potential therapeutic approach in the treatment of sporadic AD, with an increased amount of Glun2b subunit of NMDA receptors, decreased inflammation, and improvement of cognitive deficit. Expand
Elucidating the functions of brain GSK3α: Possible synergy with GSK3β upregulation and reversal by antidepressant treatment in a mouse model of depressive-like behaviour
TLDR
These results provide the first evidence for the potential involvement of GSK3α in depressive-like behaviours and as a target of anti-depressant therapy and suggest some cross-talk may exist between the two G SK3 isoforms. Expand
Thiamine and benfotiamine prevent stress-induced suppression of hippocampal neurogenesis in mice exposed to predation without affecting brain thiamine diphosphate levels
TLDR
It is demonstrated, for the first time, that thiamine and benfotiamine prevent stress‐induced inhibition of hippocampal neurogenesis and accompanying physiological changes, and might be useful as a complementary therapy in several neuropsychiatric disorders. Expand
Neuroprotective Effects of Thiamine and Precursors with Higher Bioavailability: Focus on Benfotiamine and Dibenzoylthiamine
TLDR
In vitro studies show that another thiamine thioester, dibenzoylthiamine (DBT) is even more efficient that BFT, especially with respect to its anti-inflammatory potency. Expand
Thiamine and benfotiamine counteract ultrasound-induced aggression, normalize AMPA receptor expression and plasticity markers, and reduce oxidative stress in mice
TLDR
Thiamine compounds were able to counteract ultrasound- induced aggression, which was accompanied by the normalization of markers that have been showed to be associated with ultrasound-induced aggression. Expand
Pro-neurogenic, Memory-Enhancing and Anti-stress Effects of DF302, a Novel Fluorine Gamma-Carboline Derivative with Multi-target Mechanism of Action
TLDR
DF302 exerts multi-target effects on the key mechanisms of neurodegenerative pathologies and can be considered as an optimized novel analogue of the neuroprotective agent dimebon. Expand
Thiamine Deficiency Causes Long-Lasting Neurobehavioral Deficits in Mice
TLDR
The study suggests that, even though the immediate neurobehavioral impact of TD is modest or negligible at a young age, the impact could develop and become severe during the aging process. Expand
Thiamine and benfotiamine protect neuroblastoma cells against paraquat and β-amyloid toxicity by a coenzyme-independent mechanism
Background Benfotiamine (BFT) is a synthetic thiamine precursor with high bioavailability. It is efficient in treating complications of type 2 diabetes and has beneficial effects in mouse models ofExpand
D-ribose is elevated in T1DM patients and can be involved in the onset of encephalopathy
TLDR
It is suggested that D-ribose is involved in the cognitive impairment in T1DM and may provide a potentially novel target for treating diabetic encephalopathy. Expand
Neuroinflammation and aberrant hippocampal plasticity in a mouse model of emotional stress evoked by exposure to ultrasound of alternating frequencies
TLDR
The results of this investigation have revealed that unpredictable alternating ultrasound evokes behavioural and molecular changes that are characteristic of the depressive syndrome and validates this new and simple method of modeling emotional stress in rodents. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 52 REFERENCES
GSK3β isoform‐selective regulation of depression, memory and hippocampal cell proliferation
TLDR
Increased activity of GSK3β, in the absence of overexpression or disease pathology, is sufficient to impair mood regulation, novel object recognition and hippocampal NPC proliferation, whereas hyperactive GSK2α individually does not impair these processes. Expand
Individual Differences in Behavioural Despair Predict Brain GSK-3beta Expression in Mice: The Power of a Modified Swim Test
TLDR
These findings implicate the activation of brain GSK-3beta expression in enhanced contextual conditioning of adverse memories, which is associated with an individual susceptibility to a depressive syndrome. Expand
Chronic valproic acid administration impairs contextual memory and dysregulates hippocampal GSK-3β in rats
TLDR
The VPA amnesic effect in the animal model here reported is also supported by some observations in patients and, therefore, it should be taken into account and monitored in VPA-based therapies. Expand
Hippocampal Glycogen Synthase Kinase 3β is Critical for the Antidepressant Effect of Cyclin-Dependent Kinase 5 Inhibitor in Rats
TLDR
It is demonstrated that systemic administration of Cdk5 inhibitors produced antidepressant-like actions and that inhibition of GSK3β is involved in behavioral response of Ctk5 inhibitors. Expand
Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice.
TLDR
In the animal Alzheimer's disease model, benfotiamine appears to improve the cognitive function and reduce amyloid deposition via thiamine-independent mechanisms, which are likely to include the suppression of glycogen synthase kinase-3 activities. Expand
Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments.
TLDR
Evidence that inhibition of glycogen synthase kinase-3 (GSK3) ameliorates cognitive deficits in a wide variety of animal models of CNS diseases, including Alzheimer's disease, Fragile X syndrome, Down syndrome, Parkinson's Disease, spinocerebellar ataxia type 1, traumatic brain injury, and others is reviewed. Expand
Lentiviral silencing of GSK-3β in adult dentate gyrus impairs contextual fear memory and synaptic plasticity
TLDR
This study aims to better understand the role of GSK3β in learning and memory through a more regionally, targeted approach, specifically performing lentiviral-mediated knockdown of G SK3β within the dentate gyrus (DG). Expand
Thiamine for Alzheimer's disease.
TLDR
There is no evidence that thiamine is a useful treatment for the symptoms of Alzheimer's disease, and the data are so poor and sparse that it is difficult to state almost anything of its effect in Alzheimer’s disease. Expand
Thiamine Deficiency: An Update of Pathophysiologic Mechanisms and Future Therapeutic Considerations
TLDR
Thiamine deficiency and Wernicke’s encephalopathy are reassessed in the light of more recent findings and therapeutic possibilities that may provide hope for the future for individuals with THE AUTHORS are discussed. Expand
Tlr4 upregulation in the brain accompanies depression- and anxiety-like behaviors induced by a high-cholesterol diet
TLDR
This study has demonstrated for the first time that high consumption of cholesterol results in depression- and anxiety-like changes in C57BL/6J mice and that these changes are unexpectedly associated with the increased expression ofTLR4, which suggests that TLR4 may have a distinct role in the CNS unrelated to pathogen recognition. Expand
...
1
2
3
4
5
...