Thiamine, Thiamine Phosphates, and Their Metabolizing Enzymes in Human Brain

  title={Thiamine, Thiamine Phosphates, and Their Metabolizing Enzymes in Human Brain},
  author={Lucien Bettendorff and Frank Mastrogiacomo and Stephen J. Kish and Thierry Grisar},
  journal={Journal of Neurochemistry},
Abstract: Total thiamine (the sum of thiamine and its phosphate esters) concentrations are two‐ to fourfold lower in human brain than in the brain of other mammals. There were no differences in the total thiamine content between biopsied and autopsied human brain, except that in the latter, thiamine triphosphate was undetectable. The main thiamine phosphate‐metabolizing enzymes could be detected in autopsied brain, and the kinetic parameters were comparable to those reported in other species… 

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