Thiamin nutrition and catalysis-induced instability of thiamin diphosphate.

@article{McCourt2006ThiaminNA,
  title={Thiamin nutrition and catalysis-induced instability of thiamin diphosphate.},
  author={Jennifer A McCourt and Peter F. Nixon and Ronald G. Duggleby},
  journal={The British journal of nutrition},
  year={2006},
  volume={96 4},
  pages={636-8}
}
Thiamin (vitamin B1) is required in animal diets because it is the precursor of the enzyme cofactor, thiamin diphosphate. Unlike other B vitamins, the dietary thiamin requirement is proportional to non-fat energy intake but there is no obvious biochemical reason for this relationship. In the present communication we show for two enzymes that the cofactor undergoes a slow destruction during catalysis, which may explain the interdependence of thiamin and energy intakes. 

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