Thiamin biosynthesis in Bacillus subtilis: structure of the thiazole synthase/sulfur carrier protein complex.

Abstract

Thiazole synthase is the key enzyme involved in the formation of the thiazole moiety of thiamin pyrophosphate. We have determined the structure of this enzyme in complex with ThiS, the sulfur carrier protein, at 3.15 A resolution. Thiazole synthase is a tetramer with 222 symmetry. The monomer is a (betaalpha)(8) barrel with similarities to the aldolase… (More)

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@article{Settembre2004ThiaminBI, title={Thiamin biosynthesis in Bacillus subtilis: structure of the thiazole synthase/sulfur carrier protein complex.}, author={Ethan C. Settembre and Pieter C. Dorrestein and Huili Zhai and Abhishek Chatterjee and Fred W. McLafferty and Tadhg P Begley and Steven E. Ealick}, journal={Biochemistry}, year={2004}, volume={43 37}, pages={11647-57} }