Thiamin Regresses the Anticancer Efficacy of Methotrexate in the Amelioration of Diethyl Nitrosamine-Induced Hepatocellular Carcinoma in Wistar Strain Rats

@article{Saleem2019ThiaminRT,
  title={Thiamin Regresses the Anticancer Efficacy of Methotrexate in the Amelioration of Diethyl Nitrosamine-Induced Hepatocellular Carcinoma in Wistar Strain Rats},
  author={S. Saleem and Imran Kazmi and Aftab Ahmad and Mohammed F Abuzinadah and Ali Samkari and Huda M Alkrathy and R. Khan},
  journal={Nutrition and Cancer},
  year={2019},
  volume={72},
  pages={170 - 181}
}
Abstract Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer and occurs frequently in patients with liver cirrhosis. HCC is the leading cause of cancer-related mortality around the globe. Aim: This study assessed the effects of thiamin in the anticancer activity of methotrexate (MTX) in diethyl nitrosamine (DEN) induced hepatocellular Carcinoma in Wistar strain male rats. Method: Fifty rats were randomly segregated in five groups with 10 rats in each group. HCC… Expand
1 Citations

References

SHOWING 1-10 OF 64 REFERENCES
Protective effects of Celastrol on diethylnitrosamine-induced hepatocellular carcinoma in rats and its mechanisms.
  • 27
Evaluation of Luteolin in the Prevention of N-nitrosodiethylamine-induced Hepatocellular Carcinoma Using Animal Model System
  • 21
Oxyphenbutazone promotes cytotoxicity in rats and Hep3B cellsvia suppression of PGE2 and deactivation of Wnt/β-catenin signaling pathway
  • 4
Thiamine metabolism in the liver of mice with Ehrlich ascites carcinoma.
  • 8
Beta-carotene inhibits rat liver chromosomal aberrations and DNA chain break after a single injection of diethylnitrosamine.
  • 43
  • PDF
Cytogenetic studies in Sprague-Dawley rats during the administration of a carcinogenic nitroso compound--diethylnitrosamine.
  • 19
Liver carcinogenesis: rodent models of hepatocarcinoma and cholangiocarcinoma.
  • S. de Minicis, T. Kisseleva, +6 authors M. Marzioni
  • Medicine
  • Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2013
  • 67
...
1
2
3
4
5
...