Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase.

  title={Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase.},
  author={John M Keith and Richard L Apodaca and Wei Xiao and Mark Seierstad and K. Pattabiraman and Jiejun Wu and Michael M. Webb and Mark J Karbarz and Sean M Brown and Sandy J Wilson and Brian P Scott and C J Tham and Lin Luo and James A Palmer and Michelle L Wennerholm and Sandra R. Chaplan and James Guy Breitenbucher},
  journal={Bioorganic & medicinal chemistry letters},
  volume={18 17},
A series of thiadiazolopiperazinyl aryl urea fatty acid amide hydrolase (FAAH) inhibitors is described. The molecules were found to inhibit the enzyme by acting as mechanism-based substrates, forming a covalent bond with Ser241. SAR and PK properties are presented. 

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