Theta-defensins: cyclic antimicrobial peptides produced by binary ligation of truncated alpha-defensins.

@article{Selsted2004ThetadefensinsCA,
  title={Theta-defensins: cyclic antimicrobial peptides produced by binary ligation of truncated alpha-defensins.},
  author={Michael E Selsted},
  journal={Current protein & peptide science},
  year={2004},
  volume={5 5},
  pages={
          365-71
        }
}
The first cyclic peptide discovered in animals is an antimicrobial octadecapeptide that is expressed in leukocytes of rhesus monkeys. The peptide, termed rhesus Theta-defensin 1 (RTD-1) is the prototype of a new family of antimicrobial peptides, which like the previously characterized alpha- and beta-defensin families, possesses broad spectrum microbicidal activities against bacteria, fungi, and protects mononuclear cells from infection by HIV-1. The cyclic Theta-defensin structure is essential… CONTINUE READING

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