Theta Oscillations in the Hippocampus

@article{Buzski2002ThetaOI,
  title={Theta Oscillations in the Hippocampus},
  author={Gy{\"o}rgy Buzs{\'a}ki},
  journal={Neuron},
  year={2002},
  volume={33},
  pages={325-340}
}
Theta oscillations represent the "on-line" state of the hippocampus. The extracellular currents underlying theta waves are generated mainly by the entorhinal input, CA3 (Schaffer) collaterals, and voltage-dependent Ca(2+) currents in pyramidal cell dendrites. The rhythm is believed to be critical for temporal coding/decoding of active neuronal ensembles and the modification of synaptic weights. Nevertheless, numerous critical issues regarding both the generation of theta oscillations and their… Expand
View on Elsevier
doi.org
2,688 Citations
Highly Influential Citations
271
Background Citations
1,432
Methods Citations
87
Results Citations
79

2,688 Citations

Citation Type

Citation Type

Self-generated theta oscillations in the hippocampus
TLDR
The results suggest that CA1 theta rhythm can emerge from the coupling of multiple autonomous hippocampal theta oscillators, and this work finds several intrinsic, atropine-resistant theta generators in CA1. Expand
Neural circuits underlying the generation of theta oscillations
TLDR
This review synthesizes the current knowledge on the circuitry involved in the generation of theta oscillations, from the hippocampus to extra hippocampal structures such as septal complex, entorhinal cortex and pedunculopontine tegmentum, a main trigger of theTA state through direct and indirect projections to the sePTal complex. Expand
Interneuronal mechanisms of hippocampal theta oscillation in full-scale model of the CA1 circuit
TLDR
A data-driven, supercomputer-based, full-scale (1:1) model of the CA1 area was developed and its interneurons were studied to reveal new insights into the spatiotemporal organization of theCA1 circuit during theta oscillations. Expand
Brain oscillations and memory
TLDR
Oscillatory fluctuations of local field potentials in the theta and gamma related mechanisms identified in rodent studies have significant parallels in the neurophysiology of human and non-human primate memory. Expand
Interaction between neocortical and hippocampal networks via slow oscillations.
TLDR
It is suggested that slow oscillation of the neocortex, which was discovered by Mircea Steriade, temporally coordinates the self-organized oscillations in the neoc cortex, entorhinal cortex, subiculum and hippocampus. Expand
Behavior-Dependent Coordination of Multiple Theta Dipoles in the Hippocampus
TLDR
The findings reveal a consortium of layer-specific theta dipoles (current sinks and sources) generated by the rhythmic flow of ions into and out of hippocampal cells and suggest that these different theta generators flexibly coordinate hippocampal regions and layers to support behavioral task performance. Expand
Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit
TLDR
A data-driven, supercomputer-based, full-scale (1:1) model of the rodent CA1 area is developed and its interneurons are studied during theta oscillations to reveal new insights into the spatiotemporal organization of the CA1 circuit during theTA oscillations. Expand
Synchronization of neural oscillations as a possible mechanism underlying episodic memory: a study of theta rhythm in the hippocampus.
TLDR
An autoassociative network model of the hippocampus and the entorhinal cortex was analyzed to explore mechanisms underlying episodic memory and suggests a possible role of theta oscillations in memory encoding and online processing of episodic events. Expand
Phase relations of theta oscillations in a computer model of the hippocampal CA1 field: Key role of Schaffer collaterals
TLDR
This work uses neural network modeling to study the mechanism of theta rhythm emergence in the CA1 microcircuitry and finds that the input from the CA3 field via Schaffercollaterals plays a major role in the formation of phase relations that have been observed in experiments in vivo. Expand
The Multiple Origins and Laminar Topography of the Hippocampal Theta Rhythm
TLDR
The hippocampal theta rhythm (4–10 Hz) is among the most widely studied brain rhythms and has been associated with cognitive performance in humans and spatial navigation and other memory tasks in rats. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 316 REFERENCES
Inhibitory CA1-CA3-hilar region feedback in the hippocampus.
TLDR
A longitudinally widespread, inhibitory feedback in rat brain from the CA1 area to the CA3 and hilar regions was observed, and this long-range, cross-regional inhibition may allow precise synchronization of population activity by timing the occurrence of action potentials in the principal cells. Expand
Intrinsic oscillations in CA3 hippocampal pyramids: Physiological relevance to theta rhythm generation
TLDR
It is shown that hippocampal neurons, recorded from juvenile and adult slices, are endowed with intrinsic properties that allow the generation of a steady oscillatory activity, and regularly occurring membrane potential oscillations can be detected since postnatal day 10 and their frequency increases with age, i.e., during the following 2 weeks. Expand
Pacemaker neurons for the theta rhythm and their synchronization in the septohippocampal reciprocal loop.
Hippocampal theta (4-10 Hz) oscillation represents a well-known brain rhythm implicated in spatial cognition and memory processes. Its cellular mechanisms remain a matter of debate, and previous… Expand
Oscillatory and Intermittent Synchrony in the Hippocampus: Relevance to Memory Trace Formation
The different cell populations of the hippocampus are involved in behaviorregulated intermittent population bursts (sharp-waves, (SPW) and dentate spikes) and oscillations (theta, gamma and 200 Hz).… Expand
Do septal neurons pace the hippocampal theta rhythm?
TLDR
Four models of the septo-hippocampal connections involved in theta rhythm production are reviewed as the precise roles of these projections are discussed, and in the final, consolidated model both cholinergic and GABAergic septal projection cells fire in rhythmic bursts that entrain hippocampal interneurons. Expand
Theta in hippocampal slices: Relation to synaptic responses of dentate neurons
TLDR
The results suggest that muscarinic receptors mediate theta activity resulting from a depolarization of dentate neurons. Expand
Oscillatory models of the hippocampus: A study of spatio-temporal patterns of neural activity
TLDR
Computer simulations presented here demonstrate that phase deviations between inputs from the medial septum and the entorhinal cortex can create spatial patterns of theta-rhythm phase-locking, and suggests new experiments to determine temporal and spatial synchronization. Expand
Intracellular correlates of hippocampal theta rhythm in identified pyramidal cells, granule cells, and basket cells
TLDR
Observations suggest that dendritic currents underlying theta in the awake rat may not be revealed under urethane anesthesia, and cellular‐synaptic generation of rhythmic slow activity in the hippocampus is investigated by intracellular recording from principal cells and basket cells in anesthetized rats. Expand
GABAergic modulation of hippocampal population activity: sequence learning, place field development, and the phase precession effect.
TLDR
A detailed biophysical model of hippocampal region CA3 was constructed to study how GABAergic modulation influences place field development and the learning and recall of sequence information and found periodic GABA(B)-receptor-mediated suppression of excitatory and inhibitory transmission at intrinsic but not afferent fibers resulted in sensory information about location being dominant during early portions of each theta cycle. Expand
Expression, control, and probable functional significance of the neuronal theta-rhythm
TLDR
Analysis of extracellularly recorded neuronal activity in alert rabbits, intact and after various brain lesions, in slices and transplants of the hippocampus and septum allow one to make the following conclusions. Expand
...
1
2
3
4
5
...