Thestr gene cluster for the biosynthesis of 5′-hydroxystreptomycin inStreptomyces glaucescens GLA.0 (ETH 22794): new operons and evidence for pathway-specific regulation by StrR

Two divergently oriented operons,strXU andstrVW, located within the gene cluster for 5′-hydroxystreptomycin (5′-OH-Sm) biosynthesis inStreptomyces glaucescens strain GLA.0 (ETH 22794), were analysed by DNA sequencing and transcription/regulation studies. Three genes,strU andstrVW, are conserved in a similar arrangement but in a different location within… CONTINUE READING