Thermostable ricin vaccine protects rhesus macaques against aerosolized ricin: Epitope-specific neutralizing antibodies correlate with protection.

@article{Roy2015ThermostableRV,
  title={Thermostable ricin vaccine protects rhesus macaques against aerosolized ricin: Epitope-specific neutralizing antibodies correlate with protection.},
  author={Chad J Roy and Robert N. Brey and Nicholas J Mantis and Kelly Mapes and Iliodora V Pop and Laurentiu M. Pop and Stephen L Ruback and Stephanie Z. Killeen and Lara A Doyle-Meyers and Heather S Vinet-Oliphant and Peter J. Didier and Ellen S. Vitetta},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 12},
  pages={3782-7}
}
Ricin toxin (RT) is the second most lethal toxin known; it has been designated by the CDC as a select agent. RT is made by the castor bean plant; an estimated 50,000 tons of RT are produced annually as a by-product of castor oil. RT has two subunits, a ribotoxic A chain (RTA) and galactose-binding B chain (RTB). RT binds to all mammalian cells and once internalized, a single RTA catalytically inactivates all of the ribosomes in a cell. Administered as an aerosol, RT causes rapid lung damage and… CONTINUE READING
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