Thermostable HIV-1 group O reverse transcriptase variants with the same fidelity as murine leukaemia virus reverse transcriptase.

Abstract

Wild-type HIV-1 group O RT (reverse transcriptase) shows increased thermostability in comparison with HIV-1 group M subtype B RT and MLV (murine leukaemia virus) RT. However, its utility in the amplification of RNA targets is limited by the reduced accuracy of lentiviral RTs compared with oncoretroviral RTs (i.e. MLV RT). The effects of the mutations K65R… (More)
DOI: 10.1042/BJ20101852

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@article{Barrioluengo2011ThermostableHG, title={Thermostable HIV-1 group O reverse transcriptase variants with the same fidelity as murine leukaemia virus reverse transcriptase.}, author={Ver{\'o}nica Barrioluengo and Mar Alvarez and Daniela Barbieri and Luis Men{\'e}ndez-Arias}, journal={The Biochemical journal}, year={2011}, volume={436 3}, pages={599-607} }