Thermostabilizing mutations in reovirus outer-capsid protein mu1 selected by heat inactivation of infectious subvirion particles.

@article{Middleton2007ThermostabilizingMI,
  title={Thermostabilizing mutations in reovirus outer-capsid protein mu1 selected by heat inactivation of infectious subvirion particles.},
  author={Jason K Middleton and Melina A Agosto and Tonya F. Severson and John Yin and Max L Nibert},
  journal={Virology},
  year={2007},
  volume={361 2},
  pages={
          412-25
        }
}
The 76-kDa mu1 protein of nonfusogenic mammalian reovirus is a major component of the virion outer capsid, which contains 200 mu1 trimers arranged in an incomplete T=13 lattice. In virions, mu1 is largely covered by a second major outer-capsid protein, sigma3, which limits mu1 conformational mobility. In infectious subvirion particles, from which sigma3 has been removed, mu1 is broadly exposed on the surface and can be promoted to rearrange into a protease-sensitive and hydrophobic conformer… CONTINUE READING
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