Thermosensory activation of insular cortex

  title={Thermosensory activation of insular cortex},
  author={A. D. Craig and K. Chen and Daniel Bandy and E. M. Reiman},
  journal={Nature Neuroscience},
Temperature sensation is regarded as a submodality of touch, but evidence suggests involvement of insular cortex rather than parietal somatosensory cortices. Using positron emission tomography (PET), we found contralateral activity correlated with graded cooling stimuli only in the dorsal margin of the middle/posterior insula in humans. This corresponds to the thermoreceptive- and nociceptive-specific lamina I spinothalamocortical pathway in monkeys, and can be considered an enteroceptive area… 

Anteroposterior somatotopy of innocuous cooling activation focus in human dorsal posterior insular cortex.

Using functional magnetic resonance imaging to detect activation in the dpIns by graded cooling stimuli applied to the hand and neck, unimodal foci arranged in an anteroposterior somatotopographic pattern are found, consistent with participation of the d pIns in localization as well as discrimination, and support the suggestion that the poststroke central pain syndrome associated with lesions of thedpIns is a thermoregulatory dysfunction.

Perceptual illusion of "paradoxical heat" engages the insular cortex.

Using the technique of percept-related functional MRI, a region of the right insular cortex specifically activated when subjects perceive a heat sensation in their right hand even though their skin temperature is cool or at neutral is found.

Hemispheric lateralization of somatosensory processing.

Left somatosensory neglect arising from injury to brain regions within the right cerebral hemisphere can be explained by right lateralized processing, analogous to those that process auditory and visual spatial information arising from extrapersonal space.

Reward Circuitry Activation by Noxious Thermal Stimuli

Somatosensory processing in the human inferior prefrontal cortex.

The authors' data provide evidence for at least two discrete ventral frontal brain regions responsive to somatosensory stimulation: the posterior inferior frontal gyrus (IFG) and adjacent anterior frontal operculum, and 2) the OFC.

Cold stimuli evoke potentials that can be recorded directly from parasylvian cortex in humans.

The response to cold stimuli from electrodes implanted directly over parasylvian cortex for the investigation of intractable seizures demonstrates that slow potentials can be evoked consistently over structures adjacent to the sylvian fissure in response to nonpainful cold.

Roles of the Insular Cortex in the Modulation of Pain: Insights from Brain Lesions

Results indicate that the insula may be importantly involved in tuning cortical regions to appropriately use previous cognitive information during afferent processing and suggest that a subjectively available experience of pain can be instantiated by brain mechanisms that do not require the insular cortex.



Thalamic relay site for cold perception in humans.

Data provide the first direct demonstration of a pathway mediating cold sensation and its location in the human thalamus and at some of these sites thalamic neurons were found that responded to innocuous cooling of the skin area corresponding to the stimulation-evoked cold sensations.

Functional imaging of an illusion of pain

TOUCHING warm and cool bars that are spatially interlaced produces a painful burning sensation resembling that caused by intense, noxious cold. We demonstrated previously that this thermal grill

Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography.

It is raised the possibility that several regions of the brain participate in the regulation of hunger and satiation and that insulin and free fatty acids may be metabolic modulators of postprandial brain neuronal events.

A thalamic nucleus specific for pain and temperature sensation

It is concluded that there is a specific thalamic nucleus for pain and temperature sensation in both monkey and human that fit clinical descriptions of the pain-producing region in humans.

Insula of the old world monkey. III: Efferent cortical output and comments on function

A collective consideration of afferents and efferents indicates that the insula has connections with principal sensory areas in the olfactory, gustatory, somesthetic, and auditory AI and AII modalities.

Comparison of human cerebral activation pattern during cutaneous warmth, heat pain, and deep cold pain.

PET was used to detect increases in regional cerebral blood flow in normal humans as they discriminated differences in the intensity of noxious and innocuous thermal stimulation applied to the nondominant (left) arm and significant increases in rCBF were seen in the contralateral sensorimotor cortex and lenticular nucleus.

Parietal pseudothalamic pain syndrome. Clinical features and anatomic correlates.

It is suggested that disruption of the interconnections between these cerebral cortical areas (including the second somatosensory representation, SII) and the thalamus may be responsible for producing a thalamocortical disconnection syndrome with spontaneous pain as its clinical manifestation.

A new version of the thalamic disinhibition hypothesis of central pain

Spinal neurons specifically excited by noxious or thermal stimuli: marginal zone of the dorsal horn.

HIGH-THRESHOLD MECHANORECEPTORS and their centrally projecting myelinated fibers make up a functionally distinct group of cutaneous sensory units that have been suggested as part of the afferent