Thermosensitive hydrogel system assembled by PTX-loaded copolymer nanoparticles for sustained intraperitoneal chemotherapy of peritoneal carcinomatosis.

@article{Xu2016ThermosensitiveHS,
  title={Thermosensitive hydrogel system assembled by PTX-loaded copolymer nanoparticles for sustained intraperitoneal chemotherapy of peritoneal carcinomatosis.},
  author={Shuxin Xu and Hongxia Fan and Li Yin and Jianhua Zhang and Anjie Dong and Liandong Deng and Hua Tang},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2016},
  volume={104},
  pages={
          251-9
        }
}
Intraperitoneal (IP) chemotherapy is a preferable treatment option for peritoneal carcinomatosis of malignancies by delivering chemotherapeutic drugs into the abdominal cavity. A persistent major challenge in IP chemotherapy is the need to provide effective drug concentration in the peritoneal cavity for an extended period of time. In the present work, the thermosensitive hydrogel system (PTX/PECT(gel)) assembled by PTX (paclitaxel)-loaded amphiphilic copolymer (PECT, poly (ε-caprolactone-co-1… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 30 REFERENCES

Cancer Statistics

R. Siegel, J. Ma, Z. Zou
  • 2014 64 (1)
  • 2014
VIEW 1 EXCERPT

Sustained release of PTX-incorporated nanoparticles synergized by burst release of DOX⋅HCl from thermosensitive modified PEG/PCL hydrogel to improve anti-tumor efficiency.

  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2014
VIEW 1 EXCERPT

Hyaluronic acid-based hydrogel for regional delivery of paclitaxel to intraperitoneal tumors.

  • Journal of controlled release : official journal of the Controlled Release Society
  • 2012
VIEW 2 EXCERPTS