Thermosensitive dendritic polyglycerol-based nanogels for cutaneous delivery of biomacromolecules.

  title={Thermosensitive dendritic polyglycerol-based nanogels for cutaneous delivery of biomacromolecules.},
  author={Madeleine Y Witting and Maria Angelica Molina and Katja Obst and Roswitha Plank and Katja Martina Eckl and Hans Christian Hennies and Marcelo Calder{\'o}n and Wolfgang Friess and Sarah Hedtrich},
  journal={Nanomedicine : nanotechnology, biology, and medicine},
  volume={11 5},
UNLABELLED Genetic skin diseases caused by mutations resulting in diminished protein synthesis could benefit from local substitution of the missing protein. Proteins, however, are excluded from topical applications due to their physicochemical properties. We prepared protein-loaded thermoresponsive poly(N-isopropylacrylamide)-polyglycerol-based nanogels exhibiting a thermal trigger point at 35°C, which is favorable for cutaneous applications due to the native thermal gradient of human skin. At… CONTINUE READING