Thermoreversible hyaluronan-based hydrogel supports in vitro and ex vivo disc-like differentiation of human mesenchymal stem cells.

@article{Peroglio2013ThermoreversibleHH,
  title={Thermoreversible hyaluronan-based hydrogel supports in vitro and ex vivo disc-like differentiation of human mesenchymal stem cells.},
  author={Marianna Peroglio and David Eglin and Lorin M Benneker and Mauro Alini and Sibylle Grad},
  journal={The spine journal : official journal of the North American Spine Society},
  year={2013},
  volume={13 11},
  pages={1627-39}
}
BACKGROUND CONTEXT The fate of human mesenchymal stem cells (hMSCs) supplied to the degenerating intervertebral disc (IVD) is still not fully understood and can be negatively affected by low oxygen, pH, and glucose concentration of the IVD environment. The hMSC survival and yield upon injection of compromised IVD could be improved by the use of an appropriate carrier and/or by predifferentiation of hMSCs before injection. PURPOSE To optimize hMSC culture conditions in thermoreversible… CONTINUE READING
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