Thermoresponsive Nanogel‐Encapsulated PEDOT and HSP70 Inhibitor for Improving the Depth of the Photothermal Therapeutic Effect

@article{Liu2016ThermoresponsiveNP,
  title={Thermoresponsive Nanogel‐Encapsulated PEDOT and HSP70 Inhibitor for Improving the Depth of the Photothermal Therapeutic Effect},
  author={Dongdong Liu and Liyi Ma and Yanxin An and Yu Li and Yuxin Liu and Lu Wang and Jin Guo and Jianhua Wang and Jing Zhou},
  journal={Advanced Functional Materials},
  year={2016},
  volume={26}
}
Photothermal therapy (PTT), a new, noninvasive treatment measure, has recently drawn much attention. However, due to the limited penetration depth of near‐infrared (NIR) light, PTT is focused on treating superficial tumors. Improving the depth of the therapeutic effect is a bottleneck for successful PTT. To solve this problem, a new kind of nanoplatform (Nanogel+phenylethynesulfonamide (PES)) is fabricated by using a thermo‐responsive polymer shell (poly(N‐isopropylacrylamide‐co‐acrylic acid… 
Fabrication of a pH-responsive core-shell nanosystem with a low-temperature photothermal therapy effect for treating bacterial biofilm infection.
TLDR
A facile approach to fabricate the MPDA@ZIF-8/PES nanosystem with the responsiveness of the bacterial infection environment is provided, and a promising low-temperature PTT strategy to treat bacterial biofilm-infection effectively is proposed.
Polydopamine-Encapsulated Fe3O4 with an Adsorbed HSP70 Inhibitor for Improved Photothermal Inactivation of Bacteria.
TLDR
A new type of nanoplatform fabricated by using polydopamine to encapsulate Fe3O4 and support 2-phenylethynesulfonamide that possesses the potential to be a recyclable photothermal agent for enhanced photothermal bacterial inactivation without causing secondary pollution.
Graphitic carbon nitride nanosheets as a multifunctional nanoplatform for photochemical internalization-enhanced photodynamic therapy.
TLDR
The tolerance of cancer cells to ROS is decreased by PES-induced HSP70 inactivation, and therefore the efficiency of PDT is significantly enhanced, and GCNS-PES can serve as a promising therapeutic nanoplatform for photo-controlled cancer therapy.
Gold-nanobranched-shell based drug vehicles with ultrahigh photothermal efficiency for chemo-photothermal therapy.
Biocompatible Heat-Shock Protein Inhibitor-Delivered Flowerlike Short-Wave Infrared Nanoprobe for Mild Temperature-Driven Highly Efficient Tumor Ablation.
TLDR
With minimal side effects and remarkable antitumor efficacy in vivo, Lu:Nd@NiS2-EGCG appeared to be a promising photothermal agent for enhanced PTT.
Injectable In-Situ Forming Hydrogels of Thermosensitive Polypyrrole Nanoplatforms for Precisely Synergistic Photothermal-Chemo Therapy.
The combination of PTT with chemotherapy has great potential to maximize synergistic effect of thermo-induced chemosensitization and improve treatment performance. For achieving high drug-loading
Nanoagent‐Promoted Mild‐Temperature Photothermal Therapy for Cancer Treatment
TLDR
The strategies of nanoagent‐promoted mild‐temperature PTT are highlighted and challenges and opportunities in this field are rationally proposed, and hopefully people can be encouraged by this promising anticancer therapy.
Near-Infrared Responsive Bimetallic Nanovesicles for Enhanced Synergistic Chemophotothermal Therapy.
TLDR
An ingenious nanocarrier, platinum/gold bimetallic-nanoshell-coated triptolide liposomes (Pt@Au-TP-Lips), to achieve enhanced chemophotothermal therapy against cancer, providing new insight into the development of a cooperative theranostic agent for oncotherapy.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 39 REFERENCES
Smart Cu1.75S nanocapsules with high and stable photothermal efficiency for NIR photo-triggered drug release
TLDR
Both in vitro and in vivo antitumor therapy results demonstrated that this smart nanoplatform is an effective agent for synergistic hyperthermia-based chemotherapy of cancer, demonstrating remote and noninvasive control.
Organic stealth nanoparticles for highly effective in vivo near-infrared photothermal therapy of cancer.
TLDR
To the best knowledge, this work is the first to use systemically administrated conductive polymer nanoparticles for highly effective in vivo PTT treatment in animals and encourages further explorations of those organic nanomaterials for cancer theranostic applications.
NIR photothermal therapy using polyaniline nanoparticles.
Near infrared laser-induced targeted cancer therapy using thermoresponsive polymer encapsulated gold nanorods.
TLDR
The NIR laser-induced targeted cancer thermo-chemotherapy without using targeting ligands represents a novel targeted anticancer strategy with facile control and practical efficacy.
A Low‐Toxic Multifunctional Nanoplatform Based on Cu9S5@mSiO2 Core‐Shell Nanocomposites: Combining Photothermal‐ and Chemotherapies with Infrared Thermal Imaging for Cancer Treatment
TLDR
The combination of photothermal‐ and chemotherapies demonstrates better effects of therapy on cancer treatment than individual therapy approaches in vitro and in vivo, and is beneficial to delivery of DOX into cancer cells for chemotherapy.
Smart human serum albumin-indocyanine green nanoparticles generated by programmed assembly for dual-modal imaging-guided cancer synergistic phototherapy.
TLDR
The results suggest that HSA-ICG NPs generated by programmed assembly as smart theranostic nanoplatforms are highly potential for imaging-guided cancer phototherapy with PDT/PTT synergistic effects.
A yolk-like multifunctional platform for multimodal imaging and synergistic therapy triggered by a single near-infrared light.
TLDR
The doped rare earth ions in the host endow the material with excellent UCL imaging, magnetic resonance imaging (MRI), and computed tomography (CT) imaging properties, thus realizing the target of multimodal imaging guided multiple therapies.
High-throughput synthesis of single-layer MoS2 nanosheets as a near-infrared photothermal-triggered drug delivery for effective cancer therapy.
TLDR
These functionalized MoS2 nanosheets have been developed as a chemotherapeutic drug nanocarrier for near-infrared (NIR) photothermal-triggered drug delivery, facilitating the combination of chemotherapy and photothermal therapy into one system for cancer therapy.
...
1
2
3
4
...