Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat Evidence for opposing roles of 5-HT2 and 5-HT1A receptors

@article{Gudelsky1986ThermoregulatoryRT,
  title={Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat Evidence for opposing roles of 5-HT2 and 5-HT1A receptors},
  author={Gary A. Gudelsky and James I. Koenig and Herbert Y. Meltzer},
  journal={Neuropharmacology},
  year={1986},
  volume={25},
  pages={1307-1313}
}

Changes in extracellular serotonin in rat hypothalamus affect thermoregulatory function.

The results indicate that elevating the 5-HT levels in the hypothalamus activates postsynaptic5-HT2 receptors and results in hyperthermic effects, whereas stimulation of presynaptic 5- HT1A receptors inThe hypothalamus reduces the endogenous 5-ht release andresults in hypothermic effects.

Changes in extracellular serotonin in rat hypothalamus affect thermoregulatory function.

The results indicate that elevating the 5-HT levels in the hypothalamus activates postsynaptic5-HT2 receptors and results in hyperthermic effects, whereas stimulation of presynaptic 5- HT1A receptors inThe hypothalamus reduces the endogenous 5-ht release andresults in hypothermic effects.

Suppression of the hypo- and hyperthermic responses to 5-HT agonists following the repeated administration of monoamine oxidase inhibitors

The responsiveness of these 5-HT receptor subtypes involved in thermoregulatory responses is decreased following chronic treatment of rats with monoamine oxidase inhibitors, and inhibition of both type A and B MAO is necessary for this desensitization process.

Stimulation of central 5-HT1D receptors causes hypothermia in the guinea-pig

The present data suggest that antagonism of GR46611-induced hypothermia may be useful for assessing the potency and duration of action of centrally-acting 5-HT 1D receptor antagonists in the guinea-pig.
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