Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat Evidence for opposing roles of 5-HT2 and 5-HT1A receptors

@article{Gudelsky1986ThermoregulatoryRT,
  title={Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat Evidence for opposing roles of 5-HT2 and 5-HT1A receptors},
  author={Gary A. Gudelsky and James I. Koenig and Herbert Y. Meltzer},
  journal={Neuropharmacology},
  year={1986},
  volume={25},
  pages={1307-1313}
}
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285 Citations
Highly Influential Citations
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Results Citations
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285 Citations

Serotonin 5-HT1a receptor-mediated hypothermia in mice: Absence of spare receptors and rapid induction of tolerance

Changes in extracellular serotonin in rat hypothalamus affect thermoregulatory function.

The results indicate that elevating the 5-HT levels in the hypothalamus activates postsynaptic5-HT2 receptors and results in hyperthermic effects, whereas stimulation of presynaptic 5- HT1A receptors inThe hypothalamus reduces the endogenous 5-ht release andresults in hypothermic effects.

Changes in extracellular serotonin in rat hypothalamus affect thermoregulatory function.

The results indicate that elevating the 5-HT levels in the hypothalamus activates postsynaptic5-HT2 receptors and results in hyperthermic effects, whereas stimulation of presynaptic 5- HT1A receptors inThe hypothalamus reduces the endogenous 5-ht release andresults in hypothermic effects.

5-HT1A and 5-HT2 Receptors mediate hypo- and hyperthermic effects of tryptophan in pargyline-pretreated rats

Suppression of the hypo- and hyperthermic responses to 5-HT agonists following the repeated administration of monoamine oxidase inhibitors

The responsiveness of these 5-HT receptor subtypes involved in thermoregulatory responses is decreased following chronic treatment of rats with monoamine oxidase inhibitors, and inhibition of both type A and B MAO is necessary for this desensitization process.

MDMA ('Ecstasy') enhances 5-HT1A receptor density and 8-OH-DPAT-induced hypothermia: blockade by drugs preventing 5-hydroxytryptamine depletion.

Stimulation of corticosterone and beta-endorphin secretion in the rat by selective 5-HT receptor subtype activation.

Complex actions of serotonergic agonists on cold-stimulated TSH secretion in male rats.

Involvement of 5-HT1A receptors in the antidepressant-like activity of gepirone in the forced swimming test in rats

Evidence for specific interactions between 5-HT1A and dopamine D2 receptor mechanisms in the mediation of extrapyramidal motor functions in the rat

...

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