Thermoregulatory responses of rats to conventional preparations of lipopolysaccharide are caused by lipopolysaccharide per se-- not by lipoprotein contaminants.

@article{Steiner2005ThermoregulatoryRO,
  title={Thermoregulatory responses of rats to conventional preparations of lipopolysaccharide are caused by lipopolysaccharide per se-- not by lipoprotein contaminants.},
  author={Alexandre A Steiner and Sumana Chakravarty and Jared R Robbins and Alexander S. Dragic and Jennifer R. Pan and Miles Herkenham and Andrej A. Romanovsky},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2005},
  volume={289 2},
  pages={R348-R352}
}
LPS preparations cause a variety of body temperature (T(b)) responses: monophasic fever, different phases of polyphasic fever, and hypothermia. Conventional (c) LPS preparations contain highly active lipoprotein contaminants (endotoxin proteins). Whereas LPS signals predominantly via the Toll-like receptor (TLR) 4, endotoxin proteins signal via TLR2. Several TLR2-dependent responses of immunocytes to cLPS in vitro are triggered by endotoxin proteins and not by LPS itself. We tested whether any… CONTINUE READING