Thermoregulatory and heat-shock protein response deficits in cold-exposed diabetic mice.

  title={Thermoregulatory and heat-shock protein response deficits in cold-exposed diabetic mice.},
  author={J M Matz and K P Lavoi and P N Epstein and Michael J Blake},
  journal={The American journal of physiology},
  volume={270 3 Pt 2},
Cold-induced expression of heat-shock proteins (HSPs) has been suggested to facilitate thermogenesis in brown adipose tissue (BAT). However, the regulation of this response and the mechanism supporting this facilitation have not been established. Because of the significant role of insulin in maintaining BAT thermogenesis, we employed a transgenic mouse model of diabetes to investigate the regulation and function of HSPs in BAT thermogenesis. These transgenic mice overexpress a calmodulin… CONTINUE READING


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