Thermoregulation during fever: Change of set-point or change of gain

@article{Mitchell1970ThermoregulationDF,
  title={Thermoregulation during fever: Change of set-point or change of gain},
  author={Duncan Mitchell and Jan W. Snellen and Alan Richard Atkins},
  journal={Pfl{\"u}gers Archiv},
  year={1970},
  volume={321},
  pages={293-302}
}
Thermoregulation during fever is generally described in terms of a change in the level of the reference signal in the control system. This paper presents an alternative postulate, namely that during fever the thermoregulatory control centre undergoes a pyrogen-induced change in sensitivity, or gain. This postulate is supported strongly by the behaviour of thermoregulatory neurones. Febrile and afebrile thermoregulation can be described by means of a model with no reference signal at all, but… CONTINUE READING
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