Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system.

@article{Romanovsky2007ThermoregulationSC,
  title={Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system.},
  author={Andrej A Romanovsky},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2007},
  volume={292 1},
  pages={
          R37-46
        }
}
  • A. Romanovsky
  • Published 2007
  • Biology
  • American journal of physiology. Regulatory, integrative and comparative physiology
While summarizing the current understanding of how body temperature (T(b)) is regulated, this review discusses the recent progress in the following areas: central and peripheral thermosensitivity and temperature-activated transient receptor potential (TRP) channels; afferent neuronal pathways from peripheral thermosensors; and efferent thermoeffector pathways. It is proposed that activation of temperature-sensitive TRP channels is a mechanism of peripheral thermosensitivity. Special attention… 
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References

SHOWING 1-10 OF 159 REFERENCES

Neuronal circuitries involved in thermoregulation

Evidence that peripheral rather than intracranial thermal signals induce thermoregulation

Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue.

These results implicate the POA, DMH, and rRPa in the central efferent pathways for thermogenic, metabolic, and cardiac responses to skin cooling, and suggest that these pathways can be modulated by serotonergic inputs to the medullary raphe.

Differential Thermosensor Control of Thermoregulatory Grooming, Locomotion, and Relaxed Postural Extension a

  • W. W. Roberts
  • Biology
    Annals of the New York Academy of Sciences
  • 1988
It is concluded that the relatively fractionated control of the rat's thermoregulatory behaviors by different groups of central and peripheral thermosensors makes possible a differentiation of responses to different distributions of hyperthermia between superficial and deep sensors that optimizes cost-benefit trade-offs in different kinds of heat stress.

Neuronal basis of Hammel's model for set-point thermoregulation.

  • J. Boulant
  • Biology
    Journal of applied physiology
  • 2006
In 1965, H. T. Hammel proposed a neuronal model to explain set-point thermoregulation, and recent electrophysiological and morphological studies support many of the model's major tenets.

Role of afferent pathways of heat and cold in body temperature regulation

The insular cortex forms an integrative part of the limbic system and is closely tied with the hypothalamus, the amygdala, the anterior cingulate cortex and the orbitofrontal cortex and emerges as the main coordinator of behavioral, autonomic and endocrine responses to both non-noxious and noxious thermal stimuli.

Relationship between body core and peripheral temperatures at the onset of thermoregulatory responses in rats.

The results suggest that, in rats, the contribution of thermal input from the skin to the onset of thermoregulatory responses is relatively small.

Ionic channels and conductance-based models for hypothalamic neuronal thermosensitivity.

Hodgkin-Huxley-like models suggest that most PO/AH neurons have the same types of ionic channels, but different levels of channel expression can explain the inherent properties of the various types of temperature-sensitive and insensitive neurons.

Does the preoptic anterior hypothalamus receive thermoafferent information?

The preoptic anterior hypothalamus (POAH) is considered the thermointegrative center of the mammalian brain and a question is raised as to whether or not peripheral temperature information is integrated in the POAH.

Thermoregulatory responses to lipopolysaccharide in the mouse: dependence on the dose and ambient temperature.

The present investigation identifies experimental conditions to study LPS-induced mono-, bi-, and polyphasic fevers and late hypothermia in mice and provides detailed characteristics of these responses.
...